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KMID : 0378019790220020063
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New Medical Journal
1979 Volume.22 No. 2 p.63 ~ p.68
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The Effect of Propranolol (Inderal^(®)) in Hyperthyroidism
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辛榮泰/Shin, Yong Tae
李權鈿/李重根/趙普衍/高昌舜/Lee, Kwon Jun/Lee, Joong Keun/Cho, Bo Youn/Koh, Chang-Soon
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Abstract
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The authors tried propranolol alone to 18 outpatients with hyperthyroidism in the Seoul National University Hospital from Aug. 1977 to Jan. 1979 with evaluation of! ´the change of their clinical features, T3 and T4 levels before and after the treatment.
The dose and duration of propranolol treatment seemed to have correlation with improvement of the clinical manifestations such as dysphea, palpitation, nervousness and hand tremor etc.
The mean systolic blood pressure of, the patients before treatment was 145 mmHg, the mean diastolic pressure 80 mn H; and the mean pulse rate -was .103 per minute. After treatment the mean systolic blood pressure was lowered to-128 mmHg, the mean diastolic pressure to 57 mmHg and pulse rate was decreased to 83 per minute.
In 6 patients who showed decrease of T3 RIA, pulse rate decreased from 106/min to 63/min. In 12 patients whose T3 RIA unresponded, pulse rate decreased from 103/min to 84/min.
6 of the 18 cases showed decrease of T3 RIA and among them 5 showed decrease of T4 simultaneously. 2 cases showed increase of T3 RIA after treatment and 10 cases showed nochange.
It is expected that with adequate dosage and duration of propranolol treatment for functional status of thyroid will result in reduction of T3 in cases who failed to show it.
But as other reports maintain, long term single therapy of propranolol for hyperthyroidism falls back to antithyroid drug or radioiodine treatment.
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